The total volume of fluid compartments accessible to drugs is about how many liters in an adult?

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Multiple Choice

The total volume of fluid compartments accessible to drugs is about how many liters in an adult?

Explanation:
Understanding drug distribution involves how much body fluid is available for the drug to occupy. In an average adult, total body water is about 60% of body weight, which for a 70 kg person is roughly 42 liters. This total splits into intracellular fluid (about 28 L) and extracellular fluid (about 14 L), with extracellular fluid further divided into plasma (~3 L) and interstitial fluid (~11–12 L). So the overall fluid volume accessible to many drugs is about 42 L. Note this is an estimate and varies with age, sex, and body composition (infants have higher TBW, obese individuals have lower TBW as a percentage).

Understanding drug distribution involves how much body fluid is available for the drug to occupy. In an average adult, total body water is about 60% of body weight, which for a 70 kg person is roughly 42 liters. This total splits into intracellular fluid (about 28 L) and extracellular fluid (about 14 L), with extracellular fluid further divided into plasma (3 L) and interstitial fluid (11–12 L). So the overall fluid volume accessible to many drugs is about 42 L. Note this is an estimate and varies with age, sex, and body composition (infants have higher TBW, obese individuals have lower TBW as a percentage).

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