Well perfused tissues take up more drug than poorly perfused tissues. Which option reflects this statement?',

• A. True
• B. Cannot be determined
• C. True
• D. Only for lipophilic drugs

Answer: (C)

The key idea is that tissue distribution is driven by how much blood flow a tissue receives. Drug molecules reach tissues from the bloodstream, so tissues with high perfusion get more drug delivered per unit time than tissues with low perfusion. This makes well-perfused tissues take up more drug overall, especially in the early distribution phase. Lipophilicity and tissue barriers can influence how easily a drug crosses into a tissue and how much it ultimately partitions there, but the delivery amount is primarily governed by blood flow. So, the statement is true. The other choices are not correct because perfusion-driven uptake applies across many drugs (not only lipophilic ones) and the principle isn’t something that cannot be determined from basic physiology.